Abstract
The introduction of (7'S)-methyl groups into the backbone of pyrrolidine-amide oligonucleotide mimics (POM) does not interfere with high affinity recognition of complementary nucleic acids, whereas (7'R)-methylation disrupts hybridisation significantly.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amides / chemistry*
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Biomimetic Materials / chemistry*
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Methylation
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Models, Molecular
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Molecular Structure
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Oligonucleotides / chemistry*
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Pyrrolidines / chemistry*
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Stereoisomerism
Substances
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Amides
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Oligonucleotides
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Pyrrolidines
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pyrrolidine