Increasingly irritable and close to tears: TRPA1 in inflammatory pain

Cell. 2006 Mar 24;124(6):1123-5. doi: 10.1016/j.cell.2006.03.006.

Abstract

TRP cation channels transduce mechanical, thermal, and pain-related inflammatory signals. In this issue of Cell, it is reported that TRPA1 has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritants, including those found in tear gas and garlic. In contrast, mechano- and thermosensation are normal in TRPA1-deficient mice.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review
  • Comment

MeSH terms

  • Animals
  • Inflammation*
  • Mice
  • Mice, Knockout
  • Pain*
  • TRPA1 Cation Channel
  • Tear Gases / toxicity*
  • Thermoreceptors / physiology
  • Transient Receptor Potential Channels / drug effects*
  • Transient Receptor Potential Channels / physiology*

Substances

  • TRPA1 Cation Channel
  • Tear Gases
  • Transient Receptor Potential Channels
  • Trpa1 protein, mouse