Prevalence of first-step mutants among levofloxacin-susceptible invasive isolates of Streptococcus pneumoniae in the United States

Mathias W R Pletz; Ardaman P Shergill; Lesley McGee; Bernard Beall; Cynthia G Whitney; Keith P Klugman; Active Bacterial Core Surveillance Team

doi:10.1128/AAC.50.4.1561-1563.2006

Prevalence of first-step mutants among levofloxacin-susceptible invasive isolates of Streptococcus pneumoniae in the United States

Antimicrob Agents Chemother. 2006 Apr;50(4):1561-3. doi: 10.1128/AAC.50.4.1561-1563.2006.

Authors

Mathias W R Pletz¹, Ardaman P Shergill, Lesley McGee, Bernard Beall, Cynthia G Whitney, Keith P Klugman; Active Bacterial Core Surveillance Team

Affiliation

¹ Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA. Pletz.Mathias@mh-hannover.de

Abstract

By use of a PCR-restriction fragment length polymorphism assay, we screened 496 levofloxacin-susceptible invasive pneumococcal strains (MIC<or=2 mg/liter) for quinolone resistance-determining region mutations known to confer fluoroquinolone resistance. Among those with a levofloxacin MIC of 2 mg/liter, 16.2% of isolates recovered from nursing home residents and 6.4% from non-nursing home residents had first-step mutations.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Anti-Bacterial Agents / pharmacology*
Humans
Levofloxacin*
Long-Term Care
Microbial Sensitivity Tests
Middle Aged
Mutation*
Ofloxacin / pharmacology*
Streptococcus pneumoniae / drug effects*
Streptococcus pneumoniae / genetics*

Substances

Anti-Bacterial Agents
Levofloxacin
Ofloxacin