Sequential or combination antifungal therapy with voriconazole and liposomal amphotericin B in a Guinea pig model of invasive aspergillosis

Antimicrob Agents Chemother. 2006 Apr;50(4):1567-9. doi: 10.1128/AAC.50.4.1567-1569.2006.

Abstract

We evaluated combinations of voriconazole (VRC) and liposomal amphotericin B (L-AMB) in a guinea pig invasive aspergillosis model. Simultaneous VRC and L-AMB was most effective, although VRC monotherapy was also effective. These regimens as well as sequential L-AMB followed by VRC were more effective than L-AMB alone or VRC followed by L-AMB.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amphotericin B / administration & dosage*
  • Animals
  • Antifungal Agents / administration & dosage*
  • Aspergillosis / drug therapy*
  • Disease Models, Animal
  • Drug Therapy, Combination
  • Guinea Pigs
  • Liposomes
  • Male
  • Pyrimidines / administration & dosage*
  • Triazoles / administration & dosage*
  • Voriconazole

Substances

  • Antifungal Agents
  • Liposomes
  • Pyrimidines
  • Triazoles
  • Amphotericin B
  • Voriconazole