Abstract
The ARF tumor suppressor protects us against cancer through protein-protein interactions in partially defined p53-dependent and p53-independent pathways. We performed a two-hybrid screen using ARF as bait and present the identification of several new ARF partners that may regulate its growth inhibitory signaling. The potential physiological roles of these novel ARF binding proteins in regulating ARF signaling are discussed.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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COS Cells
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Carrier Proteins / genetics*
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Carrier Proteins / isolation & purification
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Carrier Proteins / metabolism*
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Cell Transformation, Neoplastic / genetics
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Cell Transformation, Neoplastic / metabolism
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Chlorocebus aethiops
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Cyclin-Dependent Kinase Inhibitor p16
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Growth Inhibitors / genetics
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Growth Inhibitors / metabolism*
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Humans
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Mice
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NIH 3T3 Cells
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Protein Binding / genetics
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Signal Transduction / genetics*
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Tumor Suppressor Protein p14ARF / genetics
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Tumor Suppressor Protein p14ARF / metabolism*
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Two-Hybrid System Techniques
Substances
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Carrier Proteins
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Cdkn2a protein, mouse
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Cyclin-Dependent Kinase Inhibitor p16
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Growth Inhibitors
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Tumor Suppressor Protein p14ARF