Abstract
The design, synthesis, and IMPDH inhibitory activity of a series of phosphonic acid-containing analogues of mycophenolic acid are described.
MeSH terms
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Drug Evaluation, Preclinical
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Enzyme Activation / drug effects
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Enzyme Inhibitors / chemical synthesis
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / pharmacology*
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IMP Dehydrogenase / antagonists & inhibitors*
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Molecular Structure
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Mycophenolic Acid / chemical synthesis
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Mycophenolic Acid / chemistry
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Mycophenolic Acid / pharmacology*
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Organophosphonates / chemistry*
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Stereoisomerism
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Structure-Activity Relationship
Substances
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Enzyme Inhibitors
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Organophosphonates
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IMP Dehydrogenase
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Mycophenolic Acid