Outbreak of hepatitis A in two federal states of Germany: bakery products as vehicle of infection

Epidemiol Infect. 2006 Dec;134(6):1292-8. doi: 10.1017/S0950268806006212. Epub 2006 May 2.

Abstract

In April 2004, increased numbers of hepatitis A were noted in six neighbouring districts in Germany. Exploratory interviews showed that patients had consumed bakery products from company X where two employees had been diagnosed with hepatitis A in February. A case-control study of consumption of products of company X was carried out through telephone interviews. Altogether, 64 cases were identified. Fifty-two cases and 112 controls aged >or=16 years were included in the case-control study. In total, 46/52 cases and 37/112 controls had consumed company X products [odds ratio (OR) 15.5, 95% confidence interval (CI) 6.1-39.7]. Of these, 36/46 cases and 16/37 controls had consumed pastries (OR 4.7, 95% CI 1.8-12.3), 25/46 cases and 12/37 controls had consumed filled doughnuts (OR 2.5, 95% CI 1.0-6.1). Sequence analysis of the VP1-2A junction region indicated 100% strain homology between cases and an infected employee of company X. We recommended reinforcement of hygiene precautions, and consideration of a prolongation of compulsory work absence after post-exposure vaccination.

MeSH terms

  • Case-Control Studies
  • Data Collection
  • Disease Outbreaks*
  • Food Microbiology*
  • Foodborne Diseases
  • Germany / epidemiology
  • Hepatitis A / epidemiology*
  • Hepatitis A / transmission
  • Hepatitis A / virology
  • Hepatovirus / genetics*
  • Hepatovirus / isolation & purification
  • Humans
  • Hygiene
  • Interviews as Topic