Polymorphisms in the genes encoding chemokine receptor 5, interleukin-10, and monocyte chemoattractant protein 1 contribute to cytomegalovirus reactivation and disease after allogeneic stem cell transplantation

J Clin Microbiol. 2006 May;44(5):1847-50. doi: 10.1128/JCM.44.5.1847-1850.2006.

Abstract

We analyzed 90 polymorphisms in 17 genes related to immune function for association with human cytomegalovirus (HCMV) reactivation and disease in patients after allogeneic stem cell transplantation. We found relevant markers (i) in CCR5 and IL-10 genes conferring a higher risk for the development of HCMV disease and (ii) in the MCP1 gene associated with HCMV reactivation. Testing of high-risk patients for the presence of these single-nucleotide polymorphisms might be useful for individualizing antiviral prophylaxis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Case-Control Studies
  • Chemokine CCL2 / genetics*
  • Cytomegalovirus Infections / etiology*
  • Cytomegalovirus Infections / genetics
  • Cytomegalovirus Infections / immunology
  • Female
  • Humans
  • Interleukin-10 / genetics*
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide*
  • Receptors, CCR5 / genetics*
  • Risk Factors
  • Stem Cell Transplantation / adverse effects*
  • Transplantation, Homologous

Substances

  • CCL2 protein, human
  • Chemokine CCL2
  • IL10 protein, human
  • Receptors, CCR5
  • Interleukin-10