Relaxation and diffusion of perfluorocarbon gas mixtures with oxygen for lung MRI

Yulin V Chang; Mark S Conradi

doi:10.1016/j.jmr.2006.04.003

Relaxation and diffusion of perfluorocarbon gas mixtures with oxygen for lung MRI

J Magn Reson. 2006 Aug;181(2):191-8. doi: 10.1016/j.jmr.2006.04.003. Epub 2006 May 16.

Authors

Yulin V Chang¹, Mark S Conradi

Affiliation

¹ Department of Physics, Washington University, St. Louis, MO 63130, USA. ychang@wustl.edu

PMID: 16707266
DOI: 10.1016/j.jmr.2006.04.003

Abstract

We report measurements of free diffusivity D(0) and relaxation times T(1) and T(2) for pure C(2)F(6) and C(3)F(8) and their mixtures with oxygen. A simplified relaxation theory is presented and used to fit the data. The results enable spatially localized relaxation time measurements to determine the local gas concentration in lung MR images, so the free diffusivity D(0) is then known. Comparison of the measured diffusion to D(0) will express the extent of diffusion restriction and allow the local surface-to-volume ratio to be found.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Data Interpretation, Statistical
Diffusion
Diffusion Magnetic Resonance Imaging / methods*
Fluorocarbons / pharmacokinetics*
Lung / metabolism*
Oxygen / pharmacokinetics*
Phantoms, Imaging
Pulmonary Diffusing Capacity / physiology
Transducers

Substances

Fluorocarbons
Oxygen