A diallelic RFLP of the CD3-epsilon chain of the clonotypic T-lymphocyte receptor is not associated with certain autoimmune diseases

Hum Genet. 1991 Feb;86(4):363-4. doi: 10.1007/BF00201834.

Abstract

A diallelic restriction fragment length polymorphism of the CD3-epsilon (epsilon) gene, which encodes for an invariant component of the human T-lymphocyte receptor, is observed when using genomic DNA TaqI digests probed with a CD3-epsilon chain cDNA probe. This combination shows two alleles of 9.1 kb and 8.4 kb with a frequency of 0.66 and 0.34, respectively, in the Spanish population. None of these alleles is associated with susceptibility to juvenile rheumatoid arthritis (JRA) or insulin-dependent diabetes mellitus (IDDM).

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Antigens, CD / genetics*
  • Antigens, Differentiation, T-Lymphocyte / genetics*
  • Arthritis, Juvenile / genetics
  • Arthritis, Juvenile / immunology
  • Autoimmune Diseases / genetics*
  • Autoimmune Diseases / immunology
  • CD3 Complex
  • Diabetes Mellitus, Type 1 / genetics
  • Diabetes Mellitus, Type 1 / immunology
  • Female
  • Gene Frequency
  • Genotype
  • Humans
  • Macromolecular Substances
  • Male
  • Pedigree
  • Polymorphism, Restriction Fragment Length*
  • Receptors, Antigen, T-Cell / genetics*

Substances

  • Antigens, CD
  • Antigens, Differentiation, T-Lymphocyte
  • CD3 Complex
  • Macromolecular Substances
  • Receptors, Antigen, T-Cell