Eruptive melanocytic nevi of the palms and soles are a rare phenomenon which has been associated with a number of different diseases. A variety of pathogenetic mechanisms have been proposed. A 22-year-old woman with Crohn disease since 1998 presented with multiple eruptive melanocytic nevi of the palms and soles. She is the second case in the literature describing the association between Crohn disease and eruptive melanocytic nevi. In contrast to the first report by Belloni-Fortina et al., in our case the melanocytic nevi appeared only on the palms and soles.