Successful treatment of cytomegalovirus-associated haemophagocytic syndrome following paediatric orthotopic liver transplantation

J Paediatr Child Health. 2006 Jun;42(6):389-91. doi: 10.1111/j.1440-1754.2006.00879.x.

Abstract

Haemophagocytic syndrome (HPS) following orthotopic liver transplantation is a rare event which is often fatal. We report here a case of HPS in association with cytomegalovirus (CMV) reactivation. The patient was treated with a combination of antiviral agents, immunomodulatory and supportive therapy which resulted in suppression of CMV infection and resolution of the haemophagocytosis.

Publication types

  • Case Reports

MeSH terms

  • Antiviral Agents / therapeutic use
  • Child, Preschool
  • Cytomegalovirus Infections / complications*
  • Cytomegalovirus Infections / drug therapy
  • Cytomegalovirus Infections / physiopathology*
  • Humans
  • Liver Transplantation*
  • Lymphohistiocytosis, Hemophagocytic / etiology*
  • Lymphohistiocytosis, Hemophagocytic / therapy
  • Male
  • Pancytopenia / drug therapy
  • Pancytopenia / physiopathology*
  • Pancytopenia / virology
  • Postoperative Complications
  • Treatment Outcome

Substances

  • Antiviral Agents