Pentacyclic triterpenoids from leaves of Excoecaria agallocha

Chem Pharm Bull (Tokyo). 2006 Jun;54(6):920-1. doi: 10.1248/cpb.54.920.

Abstract

A new oleanane-type triterpenoid (1) and five known pentacyclic triterpenoids (2-6) were isolated from the leaves of Excoecaria agallocha. Their structures were elucidated by spectroscopic analyses. The new compound was characterized as 3beta-[(2E,4E)-5-oxo-decadienoyloxy]-olean-12-ene (1). Compounds 1-6 were found inactive in vitro against several human cancer cell lines.

MeSH terms

  • Caco-2 Cells
  • Euphorbiaceae / chemistry*
  • Humans
  • Oleanolic Acid / analogs & derivatives*
  • Oleanolic Acid / isolation & purification
  • Oleanolic Acid / pharmacology
  • Pentacyclic Triterpenes / isolation & purification
  • Pentacyclic Triterpenes / pharmacology
  • Plant Leaves / chemistry*

Substances

  • Pentacyclic Triterpenes
  • oleanane
  • Oleanolic Acid