Abstract
Two serrulatane diterpenes, 3,8-dihydroxyserrulatic acid (1) and serrulatic acid (2), have been isolated from Eremophila sturtii through bioassay-guided fractionation. These compounds inhibit the inflammation pathway enzymes cyclooxygenase 1 and 2, and exhibit bactericidal activity against Staphylococcus aureus.
MeSH terms
-
Anti-Infective Agents / chemistry
-
Anti-Infective Agents / isolation & purification
-
Anti-Infective Agents / pharmacology
-
Anti-Inflammatory Agents / chemistry
-
Anti-Inflammatory Agents / isolation & purification
-
Anti-Inflammatory Agents / pharmacology
-
Cyclooxygenase Inhibitors / chemistry
-
Cyclooxygenase Inhibitors / isolation & purification
-
Cyclooxygenase Inhibitors / pharmacology
-
Diterpenes / chemistry*
-
Diterpenes / isolation & purification
-
Diterpenes / pharmacology*
-
Eremophila Plant / chemistry*
-
Magnetic Resonance Spectroscopy
-
Microbial Sensitivity Tests
-
Plant Leaves / chemistry
-
Staphylococcus aureus / drug effects
Substances
-
3,8-dihydroxyserrulatic acid
-
Anti-Infective Agents
-
Anti-Inflammatory Agents
-
Cyclooxygenase Inhibitors
-
Diterpenes
-
serrulatic acid