Abstract
Tumor necrosis factor (TNF-alpha) significantly reduced Cryptosporidium parvum development in a murine enterocyte cell line, and a key mechanism of action appeared to be inhibition of parasite invasion. However, TNF-alpha-deficient mice controlled infection as effectively as wild-type mice. This suggests that TNF-alpha might have only a redundant role for establishing immunity against C. parvum.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cell Line
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Cryptosporidiosis / immunology*
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Cryptosporidium parvum / immunology*
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Disease Models, Animal
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Enterocytes / immunology*
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Immunity, Innate
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Mice
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Mice, Knockout
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Tumor Necrosis Factor-alpha / deficiency
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Tumor Necrosis Factor-alpha / genetics
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Tumor Necrosis Factor-alpha / physiology*
Substances
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Tumor Necrosis Factor-alpha