A 49-year old man suffered a superficial injury on the dorsum of the right hand. Subsequently, a wound developed which healed slowly despite several courses of oral antibiotics. Gradually, nodular lesions developed on the hand. A biopsy of the nodules showed granulomatous inflammation which was considered to be consistent with rheumatoid nodules. Local injections with corticosteroids were administered with only temporary relief. Eigtheen months after the original injury a biopsy was performed and sent for bacterial culture which grew Mycobacterium marinum. The patient received prolonged antimycobacterial treatment. Nevertheless, osteomyelitis eventually developed and a second course of drug therapy, as well as a surgical operation was required before the infection was eventually cured.