Abstract
Early-onset generalized dystonia attributable to a DYT1 gene mutation is a hyperkinetic movement disorder that responds poorly to pharmacotherapy. In this video brief, we show that continuous bilateral stimulation of the globus pallidus internus produced sustained and marked improvements in the motor symptoms and functional disabilities of Japanese patients with DYT1-generalized dystonia.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Child
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Chromosome Deletion
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Deep Brain Stimulation / methods*
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Disability Evaluation
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Dominance, Cerebral / physiology
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Dystonia / genetics*
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Dystonia / physiopathology
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Dystonia / therapy
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Electrodes, Implanted
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Follow-Up Studies
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Globus Pallidus / physiopathology*
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Humans
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Hyperkinesis / genetics*
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Hyperkinesis / physiopathology
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Hyperkinesis / therapy
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Japan
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Male
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Molecular Chaperones / genetics*
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Trinucleotide Repeats
Substances
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Molecular Chaperones
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TOR1A protein, human