Addition of MT, D16S10, D16S4, and D16S91 to the linkage map within 16q12.1-q22.1

H M Kozman; A K Gedeon; S Whitmore; G K Suthers; D F Callen; G R Sutherland; J C Mulley

doi:10.1016/0888-7543(91)90085-s

Addition of MT, D16S10, D16S4, and D16S91 to the linkage map within 16q12.1-q22.1

Genomics. 1991 Nov;11(3):756-9. doi: 10.1016/0888-7543(91)90085-s.

Authors

H M Kozman¹, A K Gedeon, S Whitmore, G K Suthers, D F Callen, G R Sutherland, J C Mulley

Affiliation

¹ Department of Cytogenetics and Molecular Genetics, Adelaide Children's Hospital, Australia.

PMID: 1685482
DOI: 10.1016/0888-7543(91)90085-s

Abstract

A 10-point genetic linkage map of the region 16q12.1 to 16q22.1 has been constructed using the CEPH reference families. Four loci, MT, D16S10, D16S91, and D16S4, not previously localized on a multipoint linkage map, were incorporated on the map presented here. The order of loci was cen-D16S39-MT, D16S65-D16S10-FRA16B-D16S38, D16S4, D16S91, D16S46-D16S47-HP-qter. The interval between D16S10 and 4D16S38 is 3.1 cM in males and 2.3 cM in females, and contains FRA16B. The cloning strategy for FRA16B will now be based on YAC walking from D16S10 and D16S38. The location of FRA16B between D16S10 and D16S38 provides a physical reference point for the multipoint linkage map on the short arm of chromosome 16.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Chromosome Mapping*
Chromosomes, Human, Pair 16*
Cloning, Molecular
Female
Genetic Linkage / genetics*
Genetic Markers / genetics
Humans
Male
Polymorphism, Restriction Fragment Length
Recombination, Genetic / genetics

Substances

Genetic Markers