Vaginal microbicides can interfere with nucleic acid amplification tests used for the diagnosis of Chlamydia trachomatis and Neisseria gonorrhoeae infection

Tania Crucitti; Vicky Jespers; Lut Van Damme; Eddy Van Dyck; Anne Buvé

doi:10.1016/j.diagmicrobio.2006.05.010

Vaginal microbicides can interfere with nucleic acid amplification tests used for the diagnosis of Chlamydia trachomatis and Neisseria gonorrhoeae infection

Diagn Microbiol Infect Dis. 2007 Jan;57(1):97-9. doi: 10.1016/j.diagmicrobio.2006.05.010. Epub 2006 Jul 21.

Authors

Tania Crucitti¹, Vicky Jespers, Lut Van Damme, Eddy Van Dyck, Anne Buvé

Affiliation

¹ HIV/STD Research and Intervention Unit, Institute of Tropical Medicine,155 Nationalestraat, 2000 Antwerp, Belgium. tcrucitti@itg.be

PMID: 16860515
DOI: 10.1016/j.diagmicrobio.2006.05.010

Abstract

We confirmed findings from previous studies that cellulose sulfate gel can interfere with nucleic acid amplification tests used for the detection of Chlamydia trachomatis and Neisseria gonorrhoeae. We therefore recommend that the effects of microbicide gels on diagnostic assays of sexually transmitted infections be established before starting up clinical studies.

Publication types

Clinical Trial, Phase III
Research Support, Non-U.S. Gov't

MeSH terms

Cellulose / administration & dosage
Cellulose / analogs & derivatives*
Cellulose / pharmacology
Chlamydia Infections / diagnosis*
Chlamydia Infections / microbiology
Chlamydia Infections / prevention & control
Chlamydia trachomatis / genetics
Chlamydia trachomatis / isolation & purification
Female
Gels
Gonorrhea / diagnosis*
Gonorrhea / microbiology
Gonorrhea / prevention & control
Humans
Neisseria gonorrhoeae / genetics
Neisseria gonorrhoeae / isolation & purification
Nucleic Acid Amplification Techniques* / standards
Specimen Handling / methods
Vagina / chemistry*
Vagina / microbiology

Substances

Gels
Cellulose
cellulose sulfate