Abstract
In an in vitro assessment of antimalarial combinations, dihydroartemisinin (DHA) showed no interaction or was mildly antagonistic when combined with piperaquine, pyronaridine, or naphthoquine. Interactions between 4-aminoquinolines and related drugs were also indifferent/antagonistic. The clinical significance of mildly antagonistic DHA combinations is uncertain but may become important if parasite drug sensitivity declines.
Publication types
-
Comparative Study
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Antimalarials / pharmacology*
-
Artemisinins / pharmacology*
-
Drug Combinations
-
Drug Interactions
-
In Vitro Techniques
-
Plasmodium falciparum / drug effects
-
Plasmodium falciparum / genetics
-
Plasmodium falciparum / growth & development
-
Quinolines / pharmacology*
Substances
-
Antimalarials
-
Artemisinins
-
Drug Combinations
-
Quinolines
-
piperaquine