Identification of insulin-like growth factor-binding protein-2 (IGF-BP-2) and a low molecular weight IGF-BP in human seminal plasma

J Clin Endocrinol Metab. 1990 Feb;70(2):551-3. doi: 10.1210/jcem-70-2-551.

Abstract

Three distinct binding proteins for the insulin-like growth factors (IGF-BPs) have recently had their cDNAs cloned and sequenced. We have evaluated IGF-BP expression in normal, oligospermic and azospermic human seminal plasma (SP), and have identified IGF-BP-2 in all samples. Additionally, SP contains a non-glycosylated low molecular weight IGF-BP (24K), which does not appear to be structurally or immunologically related to IGF-BP-1, -2 or -3.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Base Sequence
  • Blotting, Western
  • Carrier Proteins / analysis*
  • Carrier Proteins / genetics
  • Cloning, Molecular
  • Humans
  • Insulin-Like Growth Factor Binding Proteins
  • Male
  • Molecular Weight
  • Oligospermia / blood
  • Oligospermia / metabolism*
  • Semen / analysis*

Substances

  • Carrier Proteins
  • Insulin-Like Growth Factor Binding Proteins