Abstract
Neurotensin (NT), an endogenous brain-gut peptide, has a close anatomical and functional relationship with the mesocorticolimbic and neostriatal dopamine system. Dysregulation of NT neurotransmission in this system has been hypothesized to be involved in the pathogenesis of schizophrenia. Additionally, NT containing circuits have been demonstrated to mediate some of the mechanisms of action of antipsychotic drugs, as well as the rewarding and/or sensitizing properties of drugs of abuse. NT receptors have been suggested to be novel targets for the treatment of psychoses or drug addiction.
Publication types
-
Research Support, N.I.H., Extramural
-
Review
MeSH terms
-
Animals
-
Antipsychotic Agents / pharmacology
-
Behavior / drug effects
-
Behavior / physiology
-
Brain / pathology
-
Brain / physiopathology
-
Dopamine / physiology
-
Humans
-
Mental Disorders / drug therapy
-
Mental Disorders / physiopathology*
-
Mental Disorders / psychology
-
Nervous System Diseases / drug therapy
-
Nervous System Diseases / physiopathology*
-
Nervous System Diseases / psychology
-
Neurotensin / physiology*
-
Parkinson Disease / physiopathology
-
Receptors, Neurotensin / physiology
-
Schizophrenia / physiopathology
-
Substance-Related Disorders / physiopathology
-
Synaptic Transmission
Substances
-
Antipsychotic Agents
-
Receptors, Neurotensin
-
Neurotensin
-
Dopamine