Role for drug transporters beyond tumor resistance: hepatic functional imaging and genotyping of multidrug resistance transporters for the prediction of irinotecan toxicity

J Clin Oncol. 2006 Sep 10;24(26):4225-7. doi: 10.1200/JCO.2006.07.2355. Epub 2006 Aug 8.
No abstract available

Publication types

  • Editorial
  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • ATP Binding Cassette Transporter, Subfamily B
  • ATP Binding Cassette Transporter, Subfamily B, Member 1
  • Antineoplastic Agents, Phytogenic / adverse effects
  • Antineoplastic Agents, Phytogenic / pharmacokinetics
  • Camptothecin / adverse effects
  • Camptothecin / analogs & derivatives*
  • Camptothecin / pharmacokinetics
  • Cytochrome P-450 CYP3A
  • Cytochrome P-450 Enzyme System / genetics
  • Cytochrome P-450 Enzyme System / metabolism
  • Drug Resistance, Multiple / genetics
  • Drug Resistance, Neoplasm / genetics
  • Genotype
  • Glucuronosyltransferase / genetics*
  • Humans
  • Irinotecan
  • Liver / diagnostic imaging
  • Liver / drug effects
  • Liver / enzymology
  • Liver / metabolism*
  • Membrane Transport Proteins / genetics*
  • Multidrug Resistance-Associated Proteins / genetics
  • Organic Anion Transporters / genetics*
  • Polymorphism, Single Nucleotide
  • Predictive Value of Tests
  • Radionuclide Imaging

Substances

  • ABCB1 protein, human
  • ATP Binding Cassette Transporter, Subfamily B
  • ATP Binding Cassette Transporter, Subfamily B, Member 1
  • Antineoplastic Agents, Phytogenic
  • Membrane Transport Proteins
  • Multidrug Resistance-Associated Proteins
  • Organic Anion Transporters
  • Irinotecan
  • Cytochrome P-450 Enzyme System
  • CYP3A5 protein, human
  • Cytochrome P-450 CYP3A
  • CYP3A4 protein, human
  • UGT1A1 enzyme
  • Glucuronosyltransferase
  • Camptothecin