Unraveling the transcriptional network controlling ES cell pluripotency

Sridhar Rao; Stuart H Orkin

doi:10.1186/gb-2006-7-8-230

Unraveling the transcriptional network controlling ES cell pluripotency

Genome Biol. 2006;7(8):230. doi: 10.1186/gb-2006-7-8-230.

Authors

Sridhar Rao¹, Stuart H Orkin

Affiliation

¹ Division of Hematology-Oncology, Children's Hospital and the Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.

Abstract

Embryonic stem cells (ES cells) are powerful tools for genetic engineering and hold significant potential for regenerative medicine. Recent work provides new insights into ES cell pluripotency and delineates separate transcriptional pathways in ES cells for maintenance of the undifferentiated state and for self-renewal.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cell Differentiation* / genetics
Embryonic Stem Cells / cytology
Embryonic Stem Cells / physiology*
Humans
Leukemia Inhibitory Factor / physiology
Mice
Octamer Transcription Factor-3 / physiology
Pluripotent Stem Cells / cytology
Pluripotent Stem Cells / physiology*
RNA Interference
STAT Transcription Factors / physiology
Signal Transduction / genetics

Substances

Leukemia Inhibitory Factor
Octamer Transcription Factor-3
STAT Transcription Factors