Abstract
The hydroalcoholic extract of Maytenus krukovii bark was investigated for its in vitro mutageno-protective activities by means of the Ames Salmonella/microsome assay. The extract showed an inhibitory effect in both T98 and T100 strains against the mutagenic activity of promutagen 2-aminoanthracene but was not protective against directly acting mutagens sodium azide and 2-nitrofluorene. When tested as a radical scavenger and antioxidant it produced a dose-dependent inhibition. The extract did not show significant antibacterial properties, and was weakly active against dermatophyte and phytopathogenic fungi, but inhibited the growth of phytopathogen Pithyum ultimum.
MeSH terms
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Animals
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Anti-Bacterial Agents / administration & dosage
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Anti-Bacterial Agents / pharmacology
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Anti-Bacterial Agents / therapeutic use
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Antifungal Agents / administration & dosage
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Antifungal Agents / pharmacology*
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Antifungal Agents / therapeutic use
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Antimutagenic Agents / administration & dosage
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Antimutagenic Agents / pharmacology*
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Antimutagenic Agents / therapeutic use
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Antioxidants / administration & dosage
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Antioxidants / pharmacology
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Antioxidants / therapeutic use
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Biphenyl Compounds
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Dose-Response Relationship, Drug
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Gram-Negative Bacteria / drug effects
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Gram-Positive Bacteria / drug effects
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Male
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Maytenus*
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Microbial Sensitivity Tests
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Mitosporic Fungi / drug effects
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Mutagenicity Tests
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Phytotherapy*
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Picrates / chemistry
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Plant Bark
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Plant Extracts / administration & dosage
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Plant Extracts / pharmacology*
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Plant Extracts / therapeutic use
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Rats
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Rats, Sprague-Dawley
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Salmonella / metabolism
Substances
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Anti-Bacterial Agents
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Antifungal Agents
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Antimutagenic Agents
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Antioxidants
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Biphenyl Compounds
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Picrates
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Plant Extracts
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1,1-diphenyl-2-picrylhydrazyl