Antimutagenic, antioxidant and antimicrobial properties of Maytenus krukovii bark

Fitoterapia. 2006 Dec;77(7-8):538-45. doi: 10.1016/j.fitote.2006.06.009. Epub 2006 Jul 6.

Abstract

The hydroalcoholic extract of Maytenus krukovii bark was investigated for its in vitro mutageno-protective activities by means of the Ames Salmonella/microsome assay. The extract showed an inhibitory effect in both T98 and T100 strains against the mutagenic activity of promutagen 2-aminoanthracene but was not protective against directly acting mutagens sodium azide and 2-nitrofluorene. When tested as a radical scavenger and antioxidant it produced a dose-dependent inhibition. The extract did not show significant antibacterial properties, and was weakly active against dermatophyte and phytopathogenic fungi, but inhibited the growth of phytopathogen Pithyum ultimum.

MeSH terms

  • Animals
  • Anti-Bacterial Agents / administration & dosage
  • Anti-Bacterial Agents / pharmacology
  • Anti-Bacterial Agents / therapeutic use
  • Antifungal Agents / administration & dosage
  • Antifungal Agents / pharmacology*
  • Antifungal Agents / therapeutic use
  • Antimutagenic Agents / administration & dosage
  • Antimutagenic Agents / pharmacology*
  • Antimutagenic Agents / therapeutic use
  • Antioxidants / administration & dosage
  • Antioxidants / pharmacology
  • Antioxidants / therapeutic use
  • Biphenyl Compounds
  • Dose-Response Relationship, Drug
  • Gram-Negative Bacteria / drug effects
  • Gram-Positive Bacteria / drug effects
  • Male
  • Maytenus*
  • Microbial Sensitivity Tests
  • Mitosporic Fungi / drug effects
  • Mutagenicity Tests
  • Phytotherapy*
  • Picrates / chemistry
  • Plant Bark
  • Plant Extracts / administration & dosage
  • Plant Extracts / pharmacology*
  • Plant Extracts / therapeutic use
  • Rats
  • Rats, Sprague-Dawley
  • Salmonella / metabolism

Substances

  • Anti-Bacterial Agents
  • Antifungal Agents
  • Antimutagenic Agents
  • Antioxidants
  • Biphenyl Compounds
  • Picrates
  • Plant Extracts
  • 1,1-diphenyl-2-picrylhydrazyl