Control of Caenorhabditis elegans life history by nuclear receptor signal transduction

Exp Gerontol. 2006 Oct;41(10):904-9. doi: 10.1016/j.exger.2006.06.062. Epub 2006 Sep 11.

Abstract

Caenorhabditis elegans diapause, reproductive development, and life span are influenced by the DAF-12 nuclear hormone receptor signaling pathway. Here, we describe how this nuclear receptor integrates environmental and physiologic cues and regulates developmental age, reproduction and aging.

Publication types

  • Review

MeSH terms

  • Aging / genetics
  • Aging / physiology*
  • Animals
  • Caenorhabditis elegans / genetics
  • Caenorhabditis elegans / growth & development
  • Caenorhabditis elegans / physiology*
  • Caenorhabditis elegans Proteins / physiology*
  • Gene Expression Regulation, Developmental / genetics
  • Genes, Helminth / genetics
  • Life Cycle Stages / genetics
  • Life Cycle Stages / physiology
  • Longevity / genetics
  • Longevity / physiology
  • Models, Biological
  • Mutation / genetics
  • Receptors, Cytoplasmic and Nuclear / physiology*
  • Signal Transduction / physiology*
  • Steroids / physiology

Substances

  • Caenorhabditis elegans Proteins
  • DAF-12 protein, C elegans
  • Receptors, Cytoplasmic and Nuclear
  • Steroids