T-cell type lymphoproliferative disease of granular lymphocytes (LDGL) is equipped with a phenotypic pattern typical of effector cytotoxic cells

Leuk Res. 2007 Mar;31(3):371-7. doi: 10.1016/j.leukres.2006.06.020. Epub 2006 Sep 18.

Abstract

By analyzing the expression of several cytotoxic markers, killer-immunoglobulin-like receptors (KIRs), CD94/CD159, CD314 and natural cytotoxicity receptors (NCRs), in 22 CD3+ lymphoproliferative disease of granular lymphocyte (LDGL) patients we investigated whether granular lymphocytes (GLs) displayed the phenotype of fully differentiated cytotoxic cells. Our results demonstrate that GLs express a pattern consistent with fully differentiated CTLs. KIRs are expressed only in a fraction of patients (7/22), as is CD94/CD159 (5/22). In conclusion, GLs in CD3+ LDGL patients typically show the phenotype of fully differentiated CTL, whereas the expression of NK receptors does not represent a common feature of the proliferating clone.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • CD3 Complex / immunology
  • Cell Differentiation / immunology
  • Female
  • Humans
  • Immunophenotyping
  • Lymphocytes / immunology*
  • Lymphoproliferative Disorders / immunology*
  • Male
  • NK Cell Lectin-Like Receptor Subfamily K
  • Receptors, IgG / immunology
  • Receptors, Immunologic / biosynthesis
  • Receptors, Immunologic / immunology
  • Receptors, KIR
  • Receptors, Natural Killer Cell
  • T-Lymphocytes, Cytotoxic / immunology*

Substances

  • CD3 Complex
  • KLRK1 protein, human
  • NK Cell Lectin-Like Receptor Subfamily K
  • Receptors, IgG
  • Receptors, Immunologic
  • Receptors, KIR
  • Receptors, Natural Killer Cell