qnrA in CTX-M-producing Escherichia coli isolates from France

Antimicrob Agents Chemother. 2006 Dec;50(12):4224-8. doi: 10.1128/AAC.00904-06. Epub 2006 Sep 18.

Abstract

By PCR, we screened for qnr genes 112 clinical isolates of extended-spectrum beta-lactamase-producing Escherichia coli collected from hospitals in France during 2004. For the first time, 7.7% of CTX-M-producing E. coli isolates presented a plasmid-mediated resistance to quinolones. All strains harbored a qnrA gene located on a sul1-type class 1 integron with similar structure to the In36 integron.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Infective Agents / pharmacology
  • Drug Resistance, Bacterial / genetics
  • Escherichia coli / drug effects
  • Escherichia coli / enzymology*
  • Escherichia coli / isolation & purification*
  • France
  • Genes, Bacterial*
  • Integrons
  • Microbial Sensitivity Tests
  • Nalidixic Acid / pharmacology
  • Plasmids / genetics
  • Polymerase Chain Reaction
  • Quinolones / pharmacology
  • beta-Lactamases / biosynthesis*

Substances

  • Anti-Infective Agents
  • Quinolones
  • Nalidixic Acid
  • beta-Lactamases