Regulation of effector T cells by antigen-presenting cells via interaction of the C-type lectin MGL with CD45

Nat Immunol. 2006 Nov;7(11):1200-8. doi: 10.1038/ni1390. Epub 2006 Sep 24.

Abstract

Homeostatic control of T cells involves tight regulation of effector T cells to prevent excessive activation that can cause tissue damage and autoimmunity. Little is known, however, about whether antigen-presenting cells (APCs) are also involved in maintaining immune system homeostasis once effector T cells are stimulated. Here we found that immature APCs downregulated effector T cell function by a mechanism involving the C-type lectin MGL expressed by APCs. Glycosylation-dependent interactions of MGL with CD45 on effector T cells negatively regulated T cell receptor-mediated signaling and T cell-dependent cytokine responses, which in turn decreased T cell proliferation and increased T cell death. Thus, regulation of effector T cells by MGL expressed on APCs may provide a target for regulating chronic inflammatory and autoimmune diseases.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antigen-Presenting Cells / immunology*
  • Antigen-Presenting Cells / metabolism
  • CD4-Positive T-Lymphocytes / immunology*
  • CD4-Positive T-Lymphocytes / metabolism
  • CD8-Positive T-Lymphocytes / immunology*
  • CD8-Positive T-Lymphocytes / metabolism
  • CHO Cells
  • Cells, Cultured
  • Clone Cells
  • Cricetinae
  • Cricetulus
  • Cytokines / metabolism
  • Humans
  • Jurkat Cells
  • Lectins, C-Type / metabolism*
  • Lectins, C-Type / physiology
  • Leukocyte Common Antigens / metabolism*
  • Leukocyte Common Antigens / physiology
  • Signal Transduction / immunology

Substances

  • Cytokines
  • Lectins, C-Type
  • MGL lectin, human
  • Leukocyte Common Antigens