VISA--a pass to innate immunity

Int J Biochem Cell Biol. 2007;39(2):287-91. doi: 10.1016/j.biocel.2006.08.016. Epub 2006 Sep 14.

Abstract

Virus-induced signaling adaptor (VISA) is essential for host innate immune responses against double-stranded RNA viral infection and viral replication. It is an adaptor that activates the transcription factors nuclear factor kappaB (NF-kappaB) and interferon regulatory factor 3 (IRF3) that regulate the expression of type I interferons. The localization of VISA to the outer membrane of mitochondria and the cellular consequences of its activation implicate this protein in the cellular etiology of neurodegenerative disorders.

Publication types

  • Review

MeSH terms

  • Adaptor Proteins, Signal Transducing / genetics
  • Adaptor Proteins, Signal Transducing / immunology*
  • Animals
  • Humans
  • Immunity, Innate*
  • Interferon Regulatory Factor-3 / immunology
  • Interferon Regulatory Factor-3 / metabolism
  • Interferon Regulatory Factor-7 / immunology
  • Interferon Regulatory Factor-7 / metabolism
  • Interferon Type I / genetics
  • Mitochondria / immunology
  • NF-kappa B / metabolism
  • RNA, Double-Stranded / immunology
  • Signal Transduction
  • Virus Replication
  • Viruses / immunology*

Substances

  • Adaptor Proteins, Signal Transducing
  • Interferon Regulatory Factor-3
  • Interferon Regulatory Factor-7
  • Interferon Type I
  • MAVS protein, human
  • NF-kappa B
  • RNA, Double-Stranded
  • VISA protein, mouse