Abstract
Exercise stimulates PGC-1alpha gene expression and increases V O2max, the latter of which relates inversely with type 2 diabetes risk. Consistently, low levels of PGC-1alpha mRNA and nucleotide sequence variation at PGC-1alpha associate with lower level of V O2max and increased diabetes risk. Thus, PGC-1alpha sequence variation may interact with physical activity to modify diabetes risk via changes in oxidative energy metabolism.
MeSH terms
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Base Sequence
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Diabetes Mellitus, Type 2 / genetics*
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Diabetes Mellitus, Type 2 / physiopathology*
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Gene Expression Regulation
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Genetic Variation
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Glucose / metabolism
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Heat-Shock Proteins / genetics*
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Humans
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Motor Activity / physiology*
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Oxygen Consumption / genetics
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Oxygen Consumption / physiology
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Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
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RNA, Messenger / physiology
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Transcription Factors / genetics*
Substances
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Heat-Shock Proteins
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PPARGC1A protein, human
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Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
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RNA, Messenger
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Transcription Factors
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Glucose