PGC-1alpha gene and physical activity in type 2 diabetes mellitus

Exerc Sport Sci Rev. 2006 Oct;34(4):171-5. doi: 10.1249/01.jes.0000240021.92254.23.

Abstract

Exercise stimulates PGC-1alpha gene expression and increases V O2max, the latter of which relates inversely with type 2 diabetes risk. Consistently, low levels of PGC-1alpha mRNA and nucleotide sequence variation at PGC-1alpha associate with lower level of V O2max and increased diabetes risk. Thus, PGC-1alpha sequence variation may interact with physical activity to modify diabetes risk via changes in oxidative energy metabolism.

Publication types

  • Review

MeSH terms

  • Base Sequence
  • Diabetes Mellitus, Type 2 / genetics*
  • Diabetes Mellitus, Type 2 / physiopathology*
  • Gene Expression Regulation
  • Genetic Variation
  • Glucose / metabolism
  • Heat-Shock Proteins / genetics*
  • Humans
  • Motor Activity / physiology*
  • Oxygen Consumption / genetics
  • Oxygen Consumption / physiology
  • Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
  • RNA, Messenger / physiology
  • Transcription Factors / genetics*

Substances

  • Heat-Shock Proteins
  • PPARGC1A protein, human
  • Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
  • RNA, Messenger
  • Transcription Factors
  • Glucose