Abstract
Tst-1, a member of the POU domain gene family, is expressed in specific neurons and in myelinating glia in the mammalian nervous system. Bacterially expressed Tst-1 binds specifically to the promoter of the gene encoding myelin protein P0, a Schwann cell surface adhesion molecule. In cotransfection assays, Tst-1 can specifically repress the P0 promoter. The N-terminal part of Tst-1 protein is highly glycine- and alanine-rich, a structural feature shared by the helix-loop-helix protein TFEB.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Animals
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Base Sequence
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Cell Adhesion Molecules / genetics*
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Cloning, Molecular
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DNA-Binding Proteins / metabolism*
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Hypothalamus
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Molecular Sequence Data
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Molecular Weight
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Myelin P0 Protein
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Myelin Proteins / genetics*
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Octamer Transcription Factor-6
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Oligonucleotides / chemistry
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Promoter Regions, Genetic*
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Rats
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Transcription Factors / metabolism*
Substances
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Cell Adhesion Molecules
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DNA-Binding Proteins
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Myelin P0 Protein
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Myelin Proteins
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Oligonucleotides
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Pou3f1 protein, rat
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Transcription Factors
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Octamer Transcription Factor-6
Associated data
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GENBANK/M35697
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GENBANK/M35698
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GENBANK/M35699
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GENBANK/M35700
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GENBANK/M63712
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GENBANK/M63981
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GENBANK/M63982
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GENBANK/M73693
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GENBANK/M73694
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GENBANK/M73695