Tst-1, a member of the POU domain gene family, binds the promoter of the gene encoding the cell surface adhesion molecule P0

Mol Cell Biol. 1991 Mar;11(3):1739-44. doi: 10.1128/mcb.11.3.1739-1744.1991.

Abstract

Tst-1, a member of the POU domain gene family, is expressed in specific neurons and in myelinating glia in the mammalian nervous system. Bacterially expressed Tst-1 binds specifically to the promoter of the gene encoding myelin protein P0, a Schwann cell surface adhesion molecule. In cotransfection assays, Tst-1 can specifically repress the P0 promoter. The N-terminal part of Tst-1 protein is highly glycine- and alanine-rich, a structural feature shared by the helix-loop-helix protein TFEB.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Cell Adhesion Molecules / genetics*
  • Cloning, Molecular
  • DNA-Binding Proteins / metabolism*
  • Hypothalamus
  • Molecular Sequence Data
  • Molecular Weight
  • Myelin P0 Protein
  • Myelin Proteins / genetics*
  • Octamer Transcription Factor-6
  • Oligonucleotides / chemistry
  • Promoter Regions, Genetic*
  • Rats
  • Transcription Factors / metabolism*

Substances

  • Cell Adhesion Molecules
  • DNA-Binding Proteins
  • Myelin P0 Protein
  • Myelin Proteins
  • Oligonucleotides
  • Pou3f1 protein, rat
  • Transcription Factors
  • Octamer Transcription Factor-6

Associated data

  • GENBANK/M35697
  • GENBANK/M35698
  • GENBANK/M35699
  • GENBANK/M35700
  • GENBANK/M63712
  • GENBANK/M63981
  • GENBANK/M63982
  • GENBANK/M73693
  • GENBANK/M73694
  • GENBANK/M73695