Abstract
Nuclear Diffusion Inhibitory Signal (NIS) has been identified in human immunodeficiency virus type 1 (HIV-1) Rev as a nuclear signal peptide which modulates nucleocytoplasmic protein trafficking and intracellular stability of the HIV-1 Rev. In this study, it was discovered that antimicrobial properties are inherent in the NIS. This is a significant finding that the NIS, which does not exist solely for self defense, in fact possesses antimicrobial properties.
MeSH terms
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Active Transport, Cell Nucleus / physiology
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Anti-Bacterial Agents / pharmacology*
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Cell Nucleus / metabolism*
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Gene Products, rev / genetics
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Gene Products, rev / pharmacology*
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Gram-Negative Bacteria / drug effects
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Gram-Positive Bacteria / drug effects
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Microbial Sensitivity Tests
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Nuclear Localization Signals / genetics*
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Nuclear Localization Signals / physiology
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rev Gene Products, Human Immunodeficiency Virus
Substances
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Anti-Bacterial Agents
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Gene Products, rev
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Nuclear Localization Signals
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rev Gene Products, Human Immunodeficiency Virus
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rev protein, Human Immunodeficiency Virus-1