Enantioselective equilibration-access to chiral aldol adducts of mandelic acid esters

Org Lett. 2006 Nov 9;8(23):5353-5. doi: 10.1021/ol062252w.

Abstract

[Structure: see text] Syn-configured aldol products of mandelic acid esters and aldehydes were synthesized by the catalytic use of amines in the presence of titanium(IV) tert-butoxide. Used along with chiral N-methylephedrine, anti-configured alpha,beta-dihydroxyesters were isolated with a high degree of enantioselectivity for the first time.