The recent developments in the multi-slice CT scanner require evaluation of the clinical indications of this new tool for imaging coronary arteries. Improvements in spatial and temporal resolution with this new generation of CT (16 slices and more) allow the acquisition of coronary arteries with a sufficient quality in the majority of cases. After a short review of the technical principles of the cardiac CT, this article considers the clinical indications of this new method in the general evaluation of coronary artery disease.