Podocarpaside, a triterpenoid possessing a new backbone from Actaea podocarpa

Org Lett. 2006 Nov 23;8(24):5529-32. doi: 10.1021/ol062212s.

Abstract

Podocarpaside (1), a novel arabinoside possessing a unique triterpene skeleton was isolated from Actaea podocarpa, a closely related species to black cohosh (dietary supplement used for menopausal disorders). Podocarpaside belongs to a new class of triterpenoids, for which the name "ranunculane" is proposed. Compound 1 possesses anticomplement activity. [structure: see text].

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Actaea / chemistry*
  • Animals
  • Antineoplastic Agents / pharmacology
  • Carbohydrate Sequence
  • Cell Line, Tumor
  • Chlorocebus aethiops
  • Complement Inactivating Agents / pharmacology
  • Crystallography, X-Ray
  • HL-60 Cells
  • Humans
  • LLC-PK1 Cells
  • Magnetic Resonance Spectroscopy
  • Models, Molecular
  • Molecular Sequence Data
  • Swine
  • Triterpenes / chemical synthesis
  • Triterpenes / chemistry
  • Vero Cells

Substances

  • Antineoplastic Agents
  • Complement Inactivating Agents
  • Triterpenes
  • podocarpaside