Abstract
Ginkgetin was found to inhibit the influenza virus sialidase. Ginkgetin-sialic acid conjugates showed a significant survival effect in the influenza-virus-infected mice.
MeSH terms
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Animals
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Antiviral Agents / pharmacology*
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Biflavonoids / pharmacology
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Cell Line
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Dogs
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Enzyme Inhibitors / pharmacology
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Female
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Flavonoids / pharmacology*
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Ginkgo biloba / chemistry
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Harringtonines / chemistry
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Humans
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Indicators and Reagents
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Influenza A virus / drug effects
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Influenza B virus / drug effects
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Influenza, Human / drug therapy
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Influenza, Human / virology
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Mice
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Mice, Inbred BALB C
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Neuraminidase / antagonists & inhibitors
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Orthomyxoviridae / drug effects*
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Orthomyxoviridae / enzymology
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Survival Analysis
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Virus Replication / drug effects
Substances
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Antiviral Agents
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Biflavonoids
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Enzyme Inhibitors
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Flavonoids
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Harringtonines
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Indicators and Reagents
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ginkgetin
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Neuraminidase