Breast cancer risk associated with AURKA 91T -->A polymorphism in relation to BRCA mutations

Linda Vidarsdottir; Sigridur K Bodvarsdottir; Holmfridur Hilmarsdottir; Laufey Tryggvadottir; Jorunn E Eyfjord

doi:10.1016/j.canlet.2006.10.003

Breast cancer risk associated with AURKA 91T -->A polymorphism in relation to BRCA mutations

Cancer Lett. 2007 Jun 8;250(2):206-12. doi: 10.1016/j.canlet.2006.10.003. Epub 2006 Nov 17.

Authors

Linda Vidarsdottir¹, Sigridur K Bodvarsdottir, Holmfridur Hilmarsdottir, Laufey Tryggvadottir, Jorunn E Eyfjord

Affiliation

¹ Molecular and Cell Biology Research Laboratory, Icelandic Cancer Society, Skogarhlid 8, 105 Reykjavik, Iceland.

PMID: 17113223
DOI: 10.1016/j.canlet.2006.10.003

Abstract

In this study 759 breast cancer patients, including 9 BRCA1 and 98 BRCA2 mutation carriers, and 653 mutation-negative unaffected controls were genotyped for the AURKA 91T -->A polymorphism. Individuals homozygous for the 91A allele were found to be at increased risk of breast cancer compared to 91T homozygotes (OR=1.87; 95% CI=1.09-3.21). This association was strengthened when cases carrying BRCA mutations were excluded (OR=2.00; 95% CI=1.15-3.47). BRCA carrier cases differed from sporadic cases and their allele distribution was very similar to controls. These results show a statistically significant increased risk of sporadic breast cancer for individuals that are homozygous for the 91A allele but no effect in carriers of BRCA mutations. This may throw light on previously conflicting results.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adenine / chemistry*
Alleles
Aurora Kinase A
Aurora Kinases
Case-Control Studies
Female
Genes, BRCA1*
Genes, BRCA2*
Genetic Predisposition to Disease*
Humans
Mutation*
Polymorphism, Genetic*
Protein Serine-Threonine Kinases / genetics*
Thymine / chemistry*

Substances

AURKA protein, human
Aurora Kinase A
Aurora Kinases
Protein Serine-Threonine Kinases
Adenine
Thymine