C35 terpenoids from the bark of Calocedrus macrolepis var. formosana with activity against human cancer cell lines

Chin-Lin Hsieh; Mei-Huims Tseng; Yi-Yuan Shao; Jang-Yang Chang; Ching-Chuan Kuo; Chi-Yen Chang; Yueh-Hsiung Kuo

doi:10.1021/np0600550

C35 terpenoids from the bark of Calocedrus macrolepis var. formosana with activity against human cancer cell lines

J Nat Prod. 2006 Nov;69(11):1611-3. doi: 10.1021/np0600550.

Authors

Chin-Lin Hsieh¹, Mei-Huims Tseng, Yi-Yuan Shao, Jang-Yang Chang, Ching-Chuan Kuo, Chi-Yen Chang, Yueh-Hsiung Kuo

Affiliation

¹ Department of Chemistry, National Taiwan University, Taipei, Taiwan 106.

PMID: 17125231
DOI: 10.1021/np0600550

Abstract

Ferrugicadinol (1) and ferrugieudesmol (2), two new compounds with a unique C35 terpene skeleton, were isolated from the bark of Calocedrus macrolepis var. formosana. Their structures were elucidated principally from spectroscopic evidence. The two new C35 terpenes showed cytotoxicity against human oral epidermoid carcinoma KB cells with IC50 values ranging from 11 to 14 microM.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents, Phytogenic* / chemistry
Antineoplastic Agents, Phytogenic* / isolation & purification
Antineoplastic Agents, Phytogenic* / pharmacology
Cell Line, Tumor
Cupressaceae / chemistry*
Drug Screening Assays, Antitumor
Humans
Inhibitory Concentration 50
KB Cells
Plant Bark / chemistry
Plants, Medicinal / chemistry*
Taiwan
Terpenes* / chemistry
Terpenes* / isolation & purification
Terpenes* / pharmacology

Substances

Antineoplastic Agents, Phytogenic
Terpenes
ferrugicadinol
ferrugieudesmol