Abstract
Investigation of the culture extracts of a marine-derived Streptomyces sp. led to the isolation of three new bohemamine-type pyrrolizidine alkaloids, bohemamine B (1), bohemamine C (2), and 5-chlorobohemamine C (3). The structures were elucidated using NMR methods, and the relative stereochemistry was determined using double-pulsed-field-gradient spin echo (DPFGSE) NOE studies.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Marine Biology
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Pyrrolizidine Alkaloids / chemistry
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Pyrrolizidine Alkaloids / isolation & purification*
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Pyrrolizidine Alkaloids / pharmacology*
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Streptomyces / chemistry*
Substances
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5-chlorobohemamine C
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Pyrrolizidine Alkaloids
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bohemamine B
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bohemamine C
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bohemamine