9,10-seco-9,19-Cyclolanostane arabinosides from the roots of Actaea podocarpa

Zulfiqar Ali; Shabana I Khan; Frank R Fronczek; Ikhlas A Khan

doi:10.1016/j.phytochem.2006.10.021

9,10-seco-9,19-Cyclolanostane arabinosides from the roots of Actaea podocarpa

Phytochemistry. 2007 Feb;68(3):373-82. doi: 10.1016/j.phytochem.2006.10.021. Epub 2006 Dec 1.

Authors

Zulfiqar Ali¹, Shabana I Khan, Frank R Fronczek, Ikhlas A Khan

Affiliation

¹ National Center for Natural Products Research, University of Mississippi, MS 38677, USA.

PMID: 17141286
DOI: 10.1016/j.phytochem.2006.10.021

Abstract

Seven 9,10-seco-9,19-cyclolanostane arabinosides, named podocarpasides A-G (1-7), were isolated from the roots of Actaea podocarpa DC., a species closely related to black cohosh (a well known dietary supplement). Their structures were determined with the help of spectroscopic data including extensive 2D NMR spectroscopy. The isolates were found inactive, when tested for cytotoxic, estrogenic, and antioxidant activities in cell based assays. They were also tested for anticomplement activity against the classical pathway of complement system and only podocarpaside C (3) inhibited modest complement activity with an IC50 value of 200 microM.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Carbohydrate Conformation
Crystallography, X-Ray
Glycosides / chemistry
Glycosides / isolation & purification*
Magnetic Resonance Spectroscopy
Models, Molecular
Plant Roots / chemistry*
Ranunculaceae / chemistry*
Spectrometry, Mass, Electrospray Ionization
Spectrophotometry, Infrared

Substances

Glycosides

Grants and funding

FD-U-002071-01/FD/FDA HHS/United States