Synthesis of 5''-substituted cyclic ADP-carbocyclic-ribose as biological tools

Natsumi Sakaguchi; Takashi Kudoh; Takashi Murayama; Mitsuhiro Arisawa; Akira Matsuda; Satoshi Shuto

doi:10.1093/nass/nrl059

Synthesis of 5''-substituted cyclic ADP-carbocyclic-ribose as biological tools

Nucleic Acids Symp Ser (Oxf). 2006:(50):119-20. doi: 10.1093/nass/nrl059.

Authors

Natsumi Sakaguchi¹, Takashi Kudoh, Takashi Murayama, Mitsuhiro Arisawa, Akira Matsuda, Satoshi Shuto

Affiliation

¹ Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan.

PMID: 17150846
DOI: 10.1093/nass/nrl059

Abstract

5''-Branched cyclic ADP-carbocyclic-riboses (4 and 5) were designed as biological tools for identifying the target proteins of cyclic ADP-ribose, an intracellular Ca(2+)-mobilizing second messenger. One of the targets, 4, successfully synthesized.

MeSH terms

Adenosine / analogs & derivatives*
Adenosine / chemical synthesis
Adenosine / chemistry
Bridged-Ring Compounds / chemical synthesis
Bridged-Ring Compounds / chemistry
Calcium Signaling*

Substances

Bridged-Ring Compounds
Adenosine