Abstract
The effect of mefloquine on artesunate pharmacokinetics was assessed in 20 volunteers given artesunate for 3 days, followed > or =21 days later by combination therapy for 3 days. The areas under the concentration-time curve from 0 h to infinity for dihydroartemisinin, the active metabolite of artesunate, were similar on day 3 of the two dosing periods (P = 0.12), implying no interaction.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Antimalarials / pharmacokinetics*
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Antimalarials / pharmacology*
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Area Under Curve
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Artemisinins / blood
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Artemisinins / pharmacokinetics*
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Artesunate
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Chromatography, High Pressure Liquid
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Drug Interactions
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Humans
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Male
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Mefloquine / pharmacology*
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Middle Aged
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Sesquiterpenes / blood
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Sesquiterpenes / pharmacokinetics*
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Spectrophotometry, Ultraviolet
Substances
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Antimalarials
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Artemisinins
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Sesquiterpenes
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Artesunate
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artenimol
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Mefloquine