Gene expression profile of abdominal aortic aneurysm rupture

Edward Choke; Matthew M Thompson; Alun Jones; Evelyn Torsney; Joseph Dawson; Kenneth Laing; Hosaam Nasr; Ian M Loftus; Gillian W Cockerill

doi:10.1196/annals.1383.006

Gene expression profile of abdominal aortic aneurysm rupture

Ann N Y Acad Sci. 2006 Nov:1085:311-4. doi: 10.1196/annals.1383.006.

Authors

Edward Choke¹, Matthew M Thompson, Alun Jones, Evelyn Torsney, Joseph Dawson, Kenneth Laing, Hosaam Nasr, Ian M Loftus, Gillian W Cockerill

Affiliation

¹ Department of Cardiovascular Sciences, Academic Vascular Surgery Unit, St. George's, University of London, UK.

PMID: 17182948
DOI: 10.1196/annals.1383.006

Abstract

To search for novel transcriptional pathways that are activated in abdominal aortic aneurysm rupture, cDNA microarrays were used to compare global mRNA expression at the aneurysm rupture edge to anterior sac, and selected results were confirmed using quantitative real-time-polymerase chain reaction (QRT-PCR). This study identified apoptosis, angiogenesis, and inflammation as potentially important participants during the process of aneurysm rupture.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aortic Aneurysm, Abdominal / genetics*
Aortic Rupture / genetics*
Gene Expression
Gene Expression Profiling
Humans
Oligonucleotide Array Sequence Analysis
RNA, Messenger / genetics

Substances

RNA, Messenger