Abstract
"Families First Africa" is an international project whose main objective is to develop a pediatric vaccine that protects infants against HIV transmission during breast feeding. The vaccine being developed consists of HIV peptides matching HLA genotypes of the Western Africa population and will be administered in association with BCG vaccine which acts as a strong adjuvant. An alternative strategy is to administer a recombinant BCG vaccine with HIV gene fragments which codify for the same peptides.
Publication types
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Comparative Study
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English Abstract
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Review
MeSH terms
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AIDS Vaccines* / administration & dosage
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AIDS Vaccines* / genetics
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AIDS Vaccines* / immunology
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Adjuvants, Immunologic / administration & dosage*
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Adult
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Africa
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Animals
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BCG Vaccine / administration & dosage*
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Breast Feeding*
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Clinical Trials, Phase I as Topic
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Clinical Trials, Phase II as Topic
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Disease Models, Animal
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Epitopes
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Female
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Forecasting
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HIV Infections / prevention & control*
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HIV Infections / transmission*
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HIV-1 / genetics
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HIV-1 / immunology
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Humans
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Infant, Newborn
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Infectious Disease Transmission, Vertical*
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International Cooperation
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Therapies, Investigational
Substances
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AIDS Vaccines
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Adjuvants, Immunologic
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BCG Vaccine
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Epitopes