Abstract
We report the results of a family-based study of LRRK2 G2019S penetrance in Parkinson disease. We studied 19 families identified through the analysis of unrelated consecutive patients. The cumulative incidence of the disease was 15% at 60 years, 21% at 70 years, and 32% at 80 years. This study provides accurate estimates of G2019S penetrance by minimizing the selection bias.
Publication types
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Comparative Study
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Evaluation Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Age of Onset
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Aged
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Aged, 80 and over
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DNA Mutational Analysis
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Family Health
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Female
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Genetic Counseling / methods*
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Genetic Predisposition to Disease
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Glycine / genetics*
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Humans
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Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
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Male
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Middle Aged
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Mutation
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Parkinson Disease / genetics*
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Penetrance*
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Protein Serine-Threonine Kinases / genetics*
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Serine / genetics*
Substances
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Serine
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LRRK2 protein, human
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Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
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Protein Serine-Threonine Kinases
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Glycine