Metabolism of methenolone acetate in a veal calf

Vet Res Commun. 2007 Apr;31(3):259-72. doi: 10.1007/s11259-006-3432-z. Epub 2006 Dec 23.

Abstract

The use of anabolic steroids has been banned in the European Union since 1981. In this study, the metabolism of the anabolic steroid methenolone acetate, was investigated in a male veal calf. After daily oral administration of methenolone acetate, three main metabolites were detected in both urine and faeces samples. Among these metabolites, alpha-methenolone was apparently the main one, but 1-methyl-5alpha-androstan-3,17-diol and 3alpha-hydroxy-1-methyl-5alpha-androstan-17-one were also observed. The parent compound was still detectable in faeces. As a consequence, abuse of methenolone acetate as growth promoter can be monitored by analysing urine and faeces samples. A few days after the last treatment, however, no metabolites were observed. Alpha-methenolone was detectable in urine until 5 days after the last treatment, but in faeces no metabolites were detectable after 3 days.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anabolic Agents / metabolism*
  • Anabolic Agents / urine
  • Animals
  • Cattle / metabolism*
  • Feces / chemistry
  • Gas Chromatography-Mass Spectrometry / veterinary
  • Male
  • Methenolone / analogs & derivatives*
  • Methenolone / metabolism
  • Methenolone / urine

Substances

  • Anabolic Agents
  • Methenolone
  • methenolone acetate