Abstract
The phytotoxin and polyketide antibiotic albicidin produced by Xanthomonas albilineans is a highly potent DNA gyrase inhibitor. Low yields of albicidin production have slowed studies of its chemical structure. Heterologous expression of albicidin biosynthetic genes in X. axonopodis pv. vesicatoria resulted in a sixfold increase in albicidin production, offering promising strategies for engineering overproduction.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / biosynthesis*
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DNA, Bacterial / chemistry
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DNA, Bacterial / genetics
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Drug Resistance / genetics*
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Organic Chemicals / metabolism
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Organic Chemicals / pharmacology
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Plasmids / genetics*
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Plasmids / metabolism
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Topoisomerase II Inhibitors*
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Xanthomonas / enzymology
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Xanthomonas / genetics*
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Xanthomonas / metabolism
Substances
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Anti-Bacterial Agents
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DNA, Bacterial
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Organic Chemicals
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Topoisomerase II Inhibitors
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albicidin