Effect of isoprinosine on IL-2, IFN-gamma and IL-4 production in vivo and in vitro

S Milano; M Dieli; S Millott; M D Miceli; E Maltese; E Cillari

doi:10.1016/0192-0561(91)90055-c

Effect of isoprinosine on IL-2, IFN-gamma and IL-4 production in vivo and in vitro

Int J Immunopharmacol. 1991;13(7):1013-8. doi: 10.1016/0192-0561(91)90055-c.

Authors

S Milano¹, M Dieli, S Millott, M D Miceli, E Maltese, E Cillari

Affiliation

¹ Institute of General Pathology, University of Palermo, Italy.

PMID: 1722191
DOI: 10.1016/0192-0561(91)90055-c

Abstract

The effects of an immunopotentiating drug, isoprinosine, on the splenocytes of BALB/c mice to produce cytokines were investigated. Isoprinosine enhanced IL-2 production, upregulating the expression of IL-2 receptor in vitro. It also significantly increased the IFN-gamma secretion and decreased the IL-4 production in vivo. The significance of these findings in terms of immune regulation is discussed.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Female
In Vitro Techniques
Inosine Pranobex / pharmacology*
Interferon-gamma / biosynthesis*
Interleukin-2 / biosynthesis*
Interleukin-3 / biosynthesis
Interleukin-4 / biosynthesis*
Mice
Mice, Inbred BALB C
Spleen / drug effects
Spleen / immunology
T-Lymphocyte Subsets / drug effects
T-Lymphocyte Subsets / immunology

Substances

Interleukin-2
Interleukin-3
Interleukin-4
Interferon-gamma
Inosine Pranobex