Abstract
We constructed recombinant adenovirus vector expressing murine endostatin and evaluated the Inhibition of human umbilical vein endothelial cells (HUVEC). We proved that endostatin significantly suppressed the S phase fraction, inhibited proliferation and increased the apoptotic index of HUVEC.
Publication types
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English Abstract
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenoviridae / genetics*
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Adenoviridae / metabolism
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Animals
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Apoptosis / drug effects*
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Cell Proliferation / drug effects
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Cells, Cultured
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Endostatins / biosynthesis*
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Endostatins / genetics
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Endothelial Cells / cytology*
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Genetic Vectors / genetics
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Humans
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Mice
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Recombinant Proteins / biosynthesis*
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Recombinant Proteins / genetics
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Recombinant Proteins / pharmacology
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Umbilical Veins / cytology
Substances
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Endostatins
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Recombinant Proteins